0.25 cup barbeque sauce (such as SFQ®), or to taste
Instructions
Preheat the oven to 325 degrees F (165 degrees C).
Mix ground beef, salt, garlic powder, onion powder, black pepper, celery salt, chipotle chile powder, and cayenne pepper together in a bowl with your hands until combined. Stir in bread crumbs, egg, ketchup, mustard, and Worcestershire sauce until thoroughly combined; form into a loaf shape.
Spread barbecue sauce over the bottom of a loaf pan. Place meat mixture on top of sauce and press into the pan.
Bake in the preheated oven until no longer pink in the center, about 1 hour, 15 minutes. An instant-read thermometer inserted into the center should read at least 160 degrees F (70 degrees C). Drain the fat from the loaf pan, then invert the pan over a plate to transfer the meatloaf. Let rest for 5 minutes before slicing.