Drain juice from pineapple into a microwave-safe bowl; set fruit aside. Warm juice in the microwave for 1 minute. Stir in Jell-O gelatin until dissolved; set aside.
Beat cream cheese and whipped topping in a large bowl until smooth. Mix in crushed pineapple. Stir in gelatin mixture until well-combined.
Pour into baked pie shell. Chill in the refrigerator until filling is set, 4 to 5 hours.